Schizophrenia is a disabling, chronic psychiatric disorder with a prevalence rate of 0.5-1% in the general population.Symptoms include positive (e.g.delusions, hallucinations), negative (e.g.blunted affect, social withdrawal), as well as cognitive symptoms (e.g.memory and attention problems).Although 75-85% of patients with schizophrenia report cog

Spatial processes often drive ecosystem processes, biogeochemical cycles, and land-atmosphere feedbacks at the landscape-scale.Climate-sensitive disturbances, such as fire, land-use change, pests, and pathogens, often spread contagiously across the landscape.While the climate-change implications of these factors are often discussed, none of these p

Organophosphate (OP) pesticide residues are frequently found in the environment and food products, with their acute exposures to humans posing a risk of neurotoxicity through acetylcholinesterase (AChE) inhibition.The aim of the present study is to develop a New Approach Methodology (a population-based physiologically based kinetic Warmers and toxi

Drug discovery and development are aimed at identifying new chemical molecular entities (NCEs) with desirable pharmacokinetic profiles for high therapeutic efficacy.The plasma concentrations of NCEs are a biomarker of their efficacy and are governed by pharmacokinetic processes such as absorption, distribution, metabolism, and excretion (ADME).Poor